Alex Marquez dominated MotoGP's Spanish Grand Prix at Jerez for his and Ducati's first grand prix win of the season, as his reigning champion brother Marc crashed out early on.

Fifth-to-third immediately at the start, Alex worked his way past championship leader Marco Bezzecchi at the end of lap one, then pounced on brother Marc for the lead at Dry Sack/the Pedrosa corner.

The elder Marquez then crashed out at speed five corners later, tucking the front through the Criville right-hander - and wholly undoing the championship standings benefit of his inventive-if-fortuitous win on Saturday.

THAT WAS MASSIVE 😱@marcmarquez93 is OUT but thankfully he got up 💥#SpanishGP 🇪🇸 pic.twitter.com/GGZwFo8IbQ

There was no real intrigue out front from there on, with Bezzecchi half-threatening a challenge to Alex Marquez but soon dropping back - settling around two seconds off the race-leading Gresini rider, and ultimately finishing 1.9s back.

Bezzecchi’s Aprilia team-mate Jorge Martin, stellar off the line again, was up six places to fourth at the start - which turned into third with the Marquez crash - but was relegated out of the podium spots by Fabio Di Giannantonio on lap four.

He never bothered Di Giannantonio from there (with the VR46 man likewise unable to attack Bezzecchi), bringing the bike home in fourth.

LCR’s Johann Zarco rode a stellar race for Honda off the front row, holding fifth (and even shadowing Martin) for much of the race, but he faded considerably in the end - getting picked off in quick succession by the two Trackhouse Aprilia bikes.

Those two then had a fight of their own, with Ai Ogura - delayed for a long time earlier in the race by Enea Bastianini up ahead of him - ultimately clearing Raul Fernandez for fifth.

It was eighth place in the end for Bastianini as the lead KTM rider. He had challenged Pedro Acosta early, then got ahead for good when Acosta damaged his fairing against the back of Fernandez's Aprilia.

It left Acosta vulnerable to the likes of Pecco Bagnaia and Fermin Aldeguer, both soon coming through, though Bagnaia's race ended from ninth place with an apparent technical issue.

Acosta did gather himself to fight off KTM works team-mate Brad Binder for 10th.

Further in the pack, Fabio Quartararo had run on course for 12th for much of the race but couldn't quite keep up the defence against Franco Morbidelli (VR46 Ducati) and Luca Marini (Honda) - though did fight off Joan Mir (Honda) in the final stages, Mir hamstrung by a double long-lap penalty earned on Saturday.

Quartararo was again the only Yamaha rider scoring points as he finished 29.5s off the winner.

Apart from the works Ducatis, the only other retirement was Aprilia tester Lorenzo Savadori - potentially physically limited after being hit by Toprak Razgatlioglu the day prior.

Ducati now faces a brutal picture in the riders' standings, with Di Giannantonio 30 points back from Bezzecchi as its lead rider (and Marc Marquez 44 points back).

Martin trails Bezzecchi by 11 points.